Platinum resistance needs the mythbusters.
نویسندگان
چکیده
The authors cited a recent publication of ours in Cancer Treatment Reviews (33(4)347357), and have significantly misrepresented our findings. Our study is titled Oxaliplatin for the treatment of cisplatin-resistant cancer: A systematic review. The objective of our publication was to systematically review, platinum resistant cell lines and clinical trials using oxaliplatin to see if there is any evidence to support the commonly held belief that oxaliplatin is active in cisplatin-resistant cancer. The systematic review found that there is little evidence to support the use of oxaliplatin in cisplatin-resistant cancer and we conclude that the two drugs are actually cross-resistant at clinically relevant levels of resistance. The purpose of this publication was to hopefully stamp out the often unreferenced statement of oxaliplatin has activity in cisplatin resistant cancer that appears in almost all papers about oxaliplatin.
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عنوان ژورنال:
- Toxicology letters
دوره 180 3 شماره
صفحات -
تاریخ انتشار 2008